General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS β-Catenin Nuclear Translocation Cell Line, 2 vials. (93-0743C3)
The PathHunter U2OS β-Catenin Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the Wnt-FzGSK3β pathway. This cell line enables assessment of ligand (e.g. wnt 3a) based pathway activation via detection of resulting β-Catenin nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged β-Catenin and nuclear localized EA. Upon pathway activation, induced nuclear translocation of β-Catenin leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Eurofins Discoverx PathHunter CCR7 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0740C3)
The PathHunter CCR7 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CCR7 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CCR7. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CCR7-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen α1A Adrenoceptor Receptor Stable Cell Line, 2 vials. (HTS087C)
The ChemiScreen α1A Adrenoceptor Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRA1A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRA1A alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of ADRA1A, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ACROBiosystems CHO/Human CEACAM5 Stable Cell Line Development Service
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is also Carcinoembryonic antigen (CEA), Meconium antigen 100, CD antigen CD66e, CEACAM5 belongs to the immunoglobulin superfamily and CEA family. CEACAM5 contains seven Ig-like (immunoglobulin-like) domains. CEACAM5 is homodimer protein which binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5 is cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is receptor for E.coli Dr adhesins.
Cayman Chemical 11-cIs RetInal 2mg
An inverse agonist of opsin; isomerizes to all-trans retinal to start the phototransduction cycle of mammalian vision; binds as a partial agonist to a G121L-mutated opsin; application to compound eyes restored moth visual sensitivity almost completely
ABclonal Technology ADRA1A Rabbit pAb
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.
Biochain Institute Inc Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Liver, 2x10 ug/PK
BioChain's human DNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of DNA prepared from primary tumor and its adjacent normal tissue; PM consists of DNA prepared from primary tumor and corresponding ponding metastatic tumor. Genomic DNA in each pair is prepared from the same donor. This product line is designed foridentifying tumor-specific genes and tumor metastatic genes.
Genscript Corporation CHO-K1/OX40 Stable Cell Line
OX40 (CD134) is a member of the TNFR/TNF superfamily Costimulatory signals from OX40 to a conventional T cell promotes division and survival augmenting the clonal expansion of effector and memory populations as they are being generated to antigens OX40 additionally suppresses the differentiation and activity of Treg further amplifying this process
Eurofins Discoverx PathHunter CHO-K1 AGTR1 β-Arrestin Cell Line, 2 vials. (93-0312C2)
The PathHunter AGTR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. angiotensin II) based activation of AGTR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AGTR1 and EA-tagged β-Arrestin-2. Activation of AGTR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC hTERT-HME1; Mammary Epithelium; Human (Homo sapiens)
For-profit organizations: For every order of this item, you must provide a signed Material Transfer Agreement Addendum for Screening Application. We cannot ship this item until we receive this addendum. The person signing the addendum as the principal investigator must match the end user as listed on the applicable sales order for the item.Email the signed addendum to SalesPermits@atcc.org with a reference to both your account and sales order numbers. Once received, your addendum will be reviewed, and this item will be released for shipment if all requirements are met. Additional fees may apply if this product is being used for a screening use (ATCC ACS-2103F), and these fees will be applied after your order is confirmed. If you need assistance with your order, please contact our Customer Care team.
Amsbio LLC Lyophilized exosomes from Plasma of Healthy donors
Lyophilized exosomes from Plasma of Healthy donors
Eurofins Discoverx Ready-to-Assay C3a Anaphylotoxin Receptor Frozen Cells, 2 Vials of Cells. (HTS016RTA)
The Ready-to-Assay C3a Anaphylotoxin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. C3a) based activation of C3AR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses C3AR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of C3AR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx PathHunter CHRM4 Total Internalization U2OS Cell Line, 2 vials. (93-0902C3)
The PathHunter CHRM4 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CHRM4 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged CHRM4 and a ProLink-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CHRM4 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
